冈本视频

Analytical Chemistry and Forensic Science

The Analytical and Forensic Science Research Group develops research and provides high level of doctoral and post-doctoral training in the fields of Analytical and Bioanalytical Chemistry, Chemistry for Health and Forensic Science. Chemical, biochemical, pharmacological and pharmaceutical outputs include advanced trace chemical analysis, diverse analytical capabilities, and the full identification of chemical compositions and unknown materials, together with chemical solving processes. This group involves a network of academic staff, including experienced analytical chemists, biochemists, synthetic organic chemists, pharmaceutical scientists, and metabolomics-based statisticians, and forensics scientists and is equipped with a very wide range of analytical facilities.

The extensive expertise and experience of staff in this group has facilitated the development of a culture-of-quality that serves to promote and maintain the recruitment of doctoral training programme students. The multicomponent high-resolution NMR, liquid chromatographic- and liquid chromatographic/mass spectrometric (LC/MS) analyses of biofluids and tissues for diagnostic and prognostic purposes; bio- and chemometrics, and metabolomics, including NMR-, LC- and LC/MS-based exploratory data analysis and pattern recognition techniques (applied to the diagnosis of cancer, inflammatory disorders, lysosomal storage diseases, and oral health conditions, for example, together with determinations of the therapeutic efficacies of drugs and healthcare products, etc.) has been explored in detail, and there is currently a series of investigations focused on cancer chemotherapy, antimicrobial drug resistance, and the study of natural products as templates for future drug design.

Areas of expertise

  • Drug Discovery and Development
  • Molecular Toxicology
  • Computational Biochemistry and Analysis
  • High resolution NMR and Mass Spectrometry analyses of Biomedical and Environmental Samples
  • Water and Wastewater treatment
  • Identification of counterfeit medicines and food adulterants.

In Forensic Science, the group covers:

  • Forensic Toxicology (Post-mortem re-distribution of drugs)
  • Forensic Evidence (Novel methods for fingermark development and identification)
  • Forensic Biology (Integrating the identification of migrants and analysing the ageing process of fingermarks using an interdisciplinary strategy combining forensic biology and analytical chemistry)
  • Fire behaviour of textiles and their potential contribution to fire deaths and serious incidents.
  • Providing expert witness standards

Research projects

Prof Martin Grootveld. Major Research Interests include (1) bio- and chemometrics/metabolomics analysis (including NMR-based exploratory data analysis and pattern recognition techniques), including applications to dental diseases and oral health; (2) bioinorganic chemistry and metallodrug design, development and actions; (3) food toxicology and screening, particularly the adverse health effects of dietary lipid oxidation products; (4) nutraceutical analysis, characterisation and testing; (5) biomolecular investigations of the aetiology and pathogenesis of inflammatory and cardiovascular diseases; (6) the role of ‘oxidative stress’ in the pathogenesis of human diseases; (7) the multicomponent high-resolution NMR analysis of biofluids and tissues for diagnostic, prognostic and forensic purposes; (8) biomedical, bioanalytical and metabolomics investigations of oral diseases and the therapeutic activities of oral healthcare products; (9) the development and application of techniques for the monitoring of drugs of both clinical and forensic interest; and (10) the ‘speciation’ of metal ions in biofluids and tissues.

Prof. Grootveld was the very first researcher to apply non-stationary, low-field benchtop nuclear magnetic resonance (NMR) facilities to the multicomponent analysis of biological fluids such as human urine as early as 2014 (LinkedIn post, March 2021). He was also shortlisted as one of the top 5 PhD supervisors in the whole of the UK and Eire by FindAUniversity Ltd. in 2020. Prof. Grootveld was the recipient of 冈本视频 Faculty of Health and Life Sciences Oscar Award for Multidisciplinary Research (April 2019), and was awarded a DSc degree in 2024 for a lifetime of Excellence in Scientific Research.

Dr. Simon Wheeler’s research aims at producing fluorescent sensors for metal cations that can be used in the lysosomes of live cells. We use techniques of analytical chemistry, especially NMR and fluorimetry, to study the behaviour of fluorophores (the fluorescent part) and ionophores (the sensing part) as a way of understanding how to design in the necessary properties for such sensors. Ultimately, we want to see our molecules used to understand the roles the lysosomes in health and disease.

Dr. Kevin Farrugia is actively involved in research related to the enhancement of latent marks (fingermarks and footwear marks) in addition to integrated approaches of multiple types of evidence. Currently the main focus is on a UKRI KTP funded project working in partnership with WEST Technology Forensics to develop solvent-less applications in the recovery of latent fingermarks. 

Dr. Sarah Hall’s main area of research is investigating the fire behaviour of textiles when contaminated with oil-based products including emollients, owing to their potential contribution in fire deaths and serious incidents. Working and partnering with practitioners and organisations such as the National Fire Chiefs Council (NFCC) and the Medicines and Healthcare products Regulatory Authority (MHRA), Health trusts and Fire and Rescue Services. The research has underpinned changes in safety updates on emollient use in the UK and relabelling of emollients with the fire risk. This included working with various agencies, including the MHRA on campaigns and knowledge exchange to health care, fire professionals and the public on using emollients safely and the risk. Currently Sarah is exploring the awareness of this fire risk outside the UK and the potential of fabrics such as towels and bedding when contaminated with emollients or other oil-based personal care products to ignite during laundering processes. She is also using her analytical expertise in helping develop a method for the detection of emollients in fire debris as a stronger link of their contribution in fires, as well investigating their removal form fabrics during laundering. Other areas of research include a) the analysis of environmental and non-invasive samples for traces of pharmaceuticals in efforts to find exposure routes to vulnerable species such as vultures b) the analysis of fire debris and methods for sampling accelerants from fire scenes.

Dr. Tim Snape’s research is particularly focused on the biological activity of the molecules we make, and current interests lie in the antiviral properties of a range of privileged structures in collaboration with Dr Maitreyi Shivkumar.

Our members

  • Professor Randolph Arroo

    School of Pharmacy Head of Research

    rrjarroo@dmu.ac.uk

    +44 (0)116 250 6386

  • Dr Federico Brucoli

    Senior Lecturer in Medicinal Chemistry

    federico.brucoli@dmu.ac.uk

    +44 116 257 7443

  • Dr Kevin Farrugia

    Associate Professor in Forensic Chemistry

    kevin.farrugia@dmu.ac.uk

    +44 (0)116 366 4409

  • Professor Martin Grootveld

    Professor of Bioanalytical Chemistry and Chemical Pathology

    mgrootveld@dmu.ac.uk

    +44 (0)116 250 6443

  • Dr Sarah Hall

    Associate Professor in Analytical Forensic Chemistry

    sarah.hall@dmu.ac.uk

    +44 (0)116 207 4601

  • Professor Parvez Haris

    Professor of Biomedical Science and Head of Research for the School of Allied Health Sciences

    pharis@dmu.ac.uk

    +44 (0)116 250 6306

  • Professor Katherine Huddersman

    Professor of Enviromental Chemistry

    huddzeo1@dmu.ac.uk

    +44 (0)116 257 7134

  • Dr Emma Johnston

    Senior Lecturer in Forensic Biology

    emma.johnston@dmu.ac.uk

    0116 207 8676

  • Dr Mounir Maafi

    Senior Lecturer

    mmaafi@dmu.ac.uk

    +44 (0)116 257 7704

  • Ms Leisa Nichols-Drew

    Associate Professor Forensic Biology

    Leisa.Nichols-Drew@dmu.ac.uk

    0116 207 8891

  • Dr Avninder S Bhambra

    Associate Professor and Subject Lead - Biomedical Science

    abhambra@dmu.ac.uk

    0116 2078792

  • Dr Tiziana Sgamma

    Associate Professor/Reader in Molecular Biology

    tiziana.sgamma@dmu.ac.uk

    +44 (0)116 201 3925

  • Dr Tim Snape

    Associate Professor of Applied Chemical Science

    tim.snape@dmu.ac.uk

    0116 366 4791

  • Professor Sangeeta Tanna

    Professor of Pharmaceutical Analysis

    stanna@dmu.ac.uk

    +44 (0)116 207 8274

  • Dr Simon Wheeler

    Lecturer in Pharmaceutical Chemistry

    simon.wheeler@dmu.ac.uk

    N/A

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